Fig 2: The keratinocyte-targeted lipid-polymer nanohybrids downregulate IMQ-induced NF-?B activation leading to the decrease of cytokine and chemokine expression of psoriasis-like skin. The protein expression of (A) IFN-?, (B) IL-1ß, (C) IL-6, (D) IL-17A, (E) IL-17E, (F) IL-22, (G) IL-23, (H) TNF-a, (I) CXCL1, and (J) CXCL2 in IMQ-induced psoriatic skin. (K) Representative IHC staining for p-NF-?B. Scale bars, 100 µm. (L) Immunoblotting analysis with p-NF-?B. DSC, desmocollin; DP, desmoplakin; PG, plakoglobin; PP, plakophilin. Data are expressed as mean ± SEM (n=4). P < 0.05, ** P < 0.01, *** P < 0.001, compared with control group.